Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.6
USERS' SCORE
Good
Based on 9 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (From Lanolin)
1,250 mcg (50,000 IU)
6250%
Top Medical Research Studies
9
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
9.5
We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
8
We conducted a randomized controlled trial to investigate how vitamin D supplementation might alleviate lower back pain in patients suffering from lumbar spinal stenosis. This study involved patients with severely low vitamin D levels, specifically under 10 ng/mL. Participants were divided into two groups: one received vitamin D supplements, while the other did not.
Over a period of several weeks, we measured pain levels and functional recovery using simple questionnaires and health surveys. Notably, we observed that those who received vitamin D injections reported significant improvements in their back pain and overall quality of life compared to those who didn’t.
Our findings suggest that addressing vitamin D deficiency might play a crucial role in managing back pain for individuals with spinal stenosis who are not candidates for surgical intervention. The results demonstrate a promising correlation between high-dose vitamin D supplementation and enhanced functional outcomes in these patients.
Over a period of several weeks, we measured pain levels and functional recovery using simple questionnaires and health surveys. Notably, we observed that those who received vitamin D injections reported significant improvements in their back pain and overall quality of life compared to those who didn’t.
Our findings suggest that addressing vitamin D deficiency might play a crucial role in managing back pain for individuals with spinal stenosis who are not candidates for surgical intervention. The results demonstrate a promising correlation between high-dose vitamin D supplementation and enhanced functional outcomes in these patients.
Most Useful Reviews
9.5
Relieves back pain
A product like magic. One pill alleviates back pain and leg pain but requires follow-up. Excellent quality and wonderful ingredients at a great price. The dosage is one pill weekly.
9.5
Back pain relief
I suffered from hair loss, depression, joint pain, fatigue, and severe vitamin D deficiency. After taking this supplement, my back pain, fatigue, and depression have disappeared, thank God. The quantity is excellent, and the product has a long shelf life: one pill weekly for eight weeks.
8.3
Eases back pain
I highly recommend this product for those with deficiencies. My back pain has eased, and my hair feels healthier.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.6
- All Researches
9.5
We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
9.5
We observed a rare condition known as pregnancy-associated osteoporosis, which affected a 38-year-old woman after she gave birth. Just a month postpartum, she experienced sudden back pain due to four vertebral fractures, and her bone density was notably low, especially in the spine.
While the patient's biochemical tests were largely normal, we noted some concerning markers, including elevated urinary deoxypyridinoline and slightly reduced levels of serum vitamin D3. To address her symptoms and improve her bone health, a combination therapy consisting of neridronate, calcium, and cholecalciferol (vitamin D3) was initiated.
Encouragingly, after one month on this treatment, she reported being pain-free. Moreover, a follow-up bone density scan after six months indicated a significant improvement in her bone density in both the spine and hip areas. This suggests that while neridronate played a crucial role, it's also important to recognize the potential benefits of vitamin D3 within this treatment regimen. However, since the effects were part of a combination therapy, we cannot isolate the specific impact of vitamin D3 on back pain alone.
While the patient's biochemical tests were largely normal, we noted some concerning markers, including elevated urinary deoxypyridinoline and slightly reduced levels of serum vitamin D3. To address her symptoms and improve her bone health, a combination therapy consisting of neridronate, calcium, and cholecalciferol (vitamin D3) was initiated.
Encouragingly, after one month on this treatment, she reported being pain-free. Moreover, a follow-up bone density scan after six months indicated a significant improvement in her bone density in both the spine and hip areas. This suggests that while neridronate played a crucial role, it's also important to recognize the potential benefits of vitamin D3 within this treatment regimen. However, since the effects were part of a combination therapy, we cannot isolate the specific impact of vitamin D3 on back pain alone.
9.5
We explored the impact of various treatments, including vitamin D3, on severe back pain caused by pregnancy-related osteoporosis (PLO). In a significant case study, a 23-year-old woman experiencing debilitating back pain was treated after her first childbirth. By monitoring her bone mineral density, we noted low T- and Z-scores in her lumbar spine.
The treatment plan included teriparatide, calcium, and vitamin D3. While we observed substantial improvements in bone density and relief from pain, it’s important to note that the isolated effect of vitamin D3 is difficult to pinpoint due to its combination with other treatments.
Overall, while vitamin D3 plays a notable role alongside teriparatide in managing back pain linked to PLO, its individual effectiveness remains somewhat unclear.
The treatment plan included teriparatide, calcium, and vitamin D3. While we observed substantial improvements in bone density and relief from pain, it’s important to note that the isolated effect of vitamin D3 is difficult to pinpoint due to its combination with other treatments.
Overall, while vitamin D3 plays a notable role alongside teriparatide in managing back pain linked to PLO, its individual effectiveness remains somewhat unclear.
9
We conducted a retrospective review to uncover how vitamin D treatment impacts back pain in individuals diagnosed with adult-onset hypophosphatemic osteomalacia. In our exploration, we found that eight patients, primarily experiencing widespread musculoskeletal pain, were assessed over a span from January 2011 to December 2019.
Each patient presented with low phosphorus levels, elevated alkaline phosphatase, and indicative imaging results. Notably, back pain was reported as the most common complaint, along with muscle weakness in over half of the cases. Our findings highlighted the effectiveness of vitamin D in tandem with phosphorus supplementation, as all patients reported significant improvements in pain, muscle strength, and gait after receiving treatment.
Importantly, we noted that the specific diagnosis of each patient varied. In six cases, treatment was prompted by adefovir-induced Fanconi syndrome, while the remaining two patients had tumor-induced osteomalacia and light-chain nephropathy. This variation indicates the diverse etiologies of hypophosphatemic osteomalacia, further emphasizing the importance of targeted treatment based on individual needs.
In conclusion, our study suggests that vitamin D, especially when combined with phosphorus, plays a crucial role in alleviating back pain associated with this condition. By enhancing the understanding of the relationship between vitamin D treatment and back pain, we aim to shed light on effective management strategies for those suffering from similar symptoms.
Each patient presented with low phosphorus levels, elevated alkaline phosphatase, and indicative imaging results. Notably, back pain was reported as the most common complaint, along with muscle weakness in over half of the cases. Our findings highlighted the effectiveness of vitamin D in tandem with phosphorus supplementation, as all patients reported significant improvements in pain, muscle strength, and gait after receiving treatment.
Importantly, we noted that the specific diagnosis of each patient varied. In six cases, treatment was prompted by adefovir-induced Fanconi syndrome, while the remaining two patients had tumor-induced osteomalacia and light-chain nephropathy. This variation indicates the diverse etiologies of hypophosphatemic osteomalacia, further emphasizing the importance of targeted treatment based on individual needs.
In conclusion, our study suggests that vitamin D, especially when combined with phosphorus, plays a crucial role in alleviating back pain associated with this condition. By enhancing the understanding of the relationship between vitamin D treatment and back pain, we aim to shed light on effective management strategies for those suffering from similar symptoms.
9
We explored the effectiveness of denosumab on alleviating back pain and enhancing quality of life in post-menopausal women suffering from vertebral fractures. This study, involving 140 women aged around 70, assessed participants who received denosumab alongside calcium and vitamin D3 for a year.
While treatment with denosumab led to significant improvements in back pain disability, overall physical and mental health quality metrics, including the Spine Pain Index and the EuroQol-5D scale, were markedly more effective post-treatment.
The ongoing role of vitamin D3 remains obscured, as it was part of a combined regimen that made it challenging to isolate its individual effects on back pain. Thus, while we observed clear benefits from the denosumab treatment, the unique contribution of vitamin D3 to back pain relief requires further investigation.
While treatment with denosumab led to significant improvements in back pain disability, overall physical and mental health quality metrics, including the Spine Pain Index and the EuroQol-5D scale, were markedly more effective post-treatment.
The ongoing role of vitamin D3 remains obscured, as it was part of a combined regimen that made it challenging to isolate its individual effects on back pain. Thus, while we observed clear benefits from the denosumab treatment, the unique contribution of vitamin D3 to back pain relief requires further investigation.
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Relieves back pain
A product like magic. One pill alleviates back pain and leg pain but requires follow-up. Excellent quality and wonderful ingredients at a great price. The dosage is one pill weekly.
9.5
Back pain relief
I suffered from hair loss, depression, joint pain, fatigue, and severe vitamin D deficiency. After taking this supplement, my back pain, fatigue, and depression have disappeared, thank God. The quantity is excellent, and the product has a long shelf life: one pill weekly for eight weeks.
8.3
Eases back pain
I highly recommend this product for those with deficiencies. My back pain has eased, and my hair feels healthier.
5.5
Temporary relief
My lower back pain improves with this product but tends to return fairly quickly after use.
3.5
Aggravated symptoms
Unfortunately, this vitamin didn't suit me; I experienced pain and dizziness after one day. The quantity is small, and I’m unsure of the reason for my adverse reaction.
Frequently Asked Questions
8
Alleviates back pain
I have a vitamin D deficiency due to limited sun exposure, leading to back pain, lethargy, and depression. After the first pill, my symptoms improved. The quantity is sufficient for multiple users, with a recommended dose of one pill weekly for three months.
8.8
Reduces back pain
I was prescribed D3 50,000 ME daily due to a lumbar vertebra compression fracture. After two weeks, my relative moved more easily and complained less about back pain. Thank you, iHerb, for fast shipping.
9.5
Back pain relief
I suffered from hair loss, depression, joint pain, fatigue, and severe vitamin D deficiency. After taking this supplement, my back pain, fatigue, and depression have disappeared, thank God. The quantity is excellent, and the product has a long shelf life: one pill weekly for eight weeks.
5.5
Temporary relief
My lower back pain improves with this product but tends to return fairly quickly after use.
9.5
Relieves back pain
A product like magic. One pill alleviates back pain and leg pain but requires follow-up. Excellent quality and wonderful ingredients at a great price. The dosage is one pill weekly.
3.5
Aggravated symptoms
Unfortunately, this vitamin didn't suit me; I experienced pain and dizziness after one day. The quantity is small, and I’m unsure of the reason for my adverse reaction.
2
We examined the effectiveness of vitamin D supplementation for people dealing with chronic low back pain (CLBP). Through a systematic review of randomized controlled trials, we focused on understanding whether vitamin D could bring any relief to those suffering from this persistent discomfort.
Our analysis of ten trials found that vitamin D supplementation did not lead to significant reductions in pain levels compared to control groups. This held true regardless of participants' initial vitamin D levels, and even long-term use did not show considerable improvements in pain outcomes. Interestingly, using active forms of vitamin D also failed to provide the hoped-for relief.
Despite these findings, it’s important to note that vitamin D might still play a role in a broader treatment plan for CLBP. However, as of now, there isn’t enough evidence to suggest that it can independently alleviate the pain. Further investigation is necessary to understand the potential long-term effects and the reasons behind the lack of benefit observed in our study.
Our analysis of ten trials found that vitamin D supplementation did not lead to significant reductions in pain levels compared to control groups. This held true regardless of participants' initial vitamin D levels, and even long-term use did not show considerable improvements in pain outcomes. Interestingly, using active forms of vitamin D also failed to provide the hoped-for relief.
Despite these findings, it’s important to note that vitamin D might still play a role in a broader treatment plan for CLBP. However, as of now, there isn’t enough evidence to suggest that it can independently alleviate the pain. Further investigation is necessary to understand the potential long-term effects and the reasons behind the lack of benefit observed in our study.
9.5
We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
8
Vitamin D3 helps alleviate back pain
We investigated whether vitamin D3 supplementation could help alleviate back pain in patients with lumbar spinal stenosis who are not undergoing surgery. This study involved patients with low vitamin D levels and split them into two groups: one received vitamin D3 supplements and the other did not.
Over several weeks, we measured changes in back pain, spinal function, and quality of life. Those in the supplementation group reported improvements in their lower back pain, demonstrating that high-dose vitamin D3 can play a significant role in managing symptoms associated with spinal stenosis.
The results suggest that for patients struggling with vitamin D deficiency and spinal stenosis, receiving vitamin D3 injections could significantly enhance both their pain levels and overall well-being.
Over several weeks, we measured changes in back pain, spinal function, and quality of life. Those in the supplementation group reported improvements in their lower back pain, demonstrating that high-dose vitamin D3 can play a significant role in managing symptoms associated with spinal stenosis.
The results suggest that for patients struggling with vitamin D deficiency and spinal stenosis, receiving vitamin D3 injections could significantly enhance both their pain levels and overall well-being.
9
We investigated the impact of adding 4000 IU of vitamin D3 on managing musculoskeletal pain, which includes back pain. In our study, we designed a randomized, double-blind, placebo-controlled trial involving 80 patients over three months. Each participant received either the vitamin D supplement or a placebo while their pain levels were monitored.
Our findings revealed that the group taking vitamin D experienced greater improvements in their pain levels, as measured by the Visual Analogue Scale (VAS). Notably, they reported a significant decline in pain compared to those receiving the placebo. Additionally, the need for rescue analgesics was markedly reduced among patients receiving vitamin D.
We also observed interesting changes in inflammatory markers. Specifically, levels of tumor necrosis factor alpha (TNFα) and prostaglandin E2 (PGE2) dropped significantly in the vitamin D group, indicating less inflammation compared to the placebo group, which actually saw increases in these markers.
In conclusion, incorporating a high dose of vitamin D may provide relief for those suffering from musculoskeletal pain, potentially through its effects on inflammation and pain perception.
Our findings revealed that the group taking vitamin D experienced greater improvements in their pain levels, as measured by the Visual Analogue Scale (VAS). Notably, they reported a significant decline in pain compared to those receiving the placebo. Additionally, the need for rescue analgesics was markedly reduced among patients receiving vitamin D.
We also observed interesting changes in inflammatory markers. Specifically, levels of tumor necrosis factor alpha (TNFα) and prostaglandin E2 (PGE2) dropped significantly in the vitamin D group, indicating less inflammation compared to the placebo group, which actually saw increases in these markers.
In conclusion, incorporating a high dose of vitamin D may provide relief for those suffering from musculoskeletal pain, potentially through its effects on inflammation and pain perception.
References
- Lee TJ, Tsai RY, Ho CC, Chen CM, Li CP. Updated Meta-analysis Reveals Limited Efficacy of Vitamin D Supplementation in Chronic Low Back Pain. In Vivo. 2024;38:2955. doi:10.21873/invivo.13778
- Bose S, Mohanasundaram K, Rajalakshmi KV, Perumal Kumaresan A, Simon J. An Unusual Mimic of Axial Spondyloarthritis: A Case Report. Cureus. 2024;16:e61441. doi:10.7759/cureus.61441
- V N, Nair GG, Jose BC, Abraham A. Study on Vitamin D Levels in 30 to 40-Year-Old Females With Low Back Pain. Cureus. 2024;16:e54238. doi:10.7759/cureus.54238
- Scaturro D, Vitagliani F, Tomasello S, Sconza C, Respizzi S, et al. Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial. Medicina (Kaunas). 2023;59. doi:10.3390/medicina59122197
- Kim S, Kim SW, Lee BC, Kim DH, Sung DH. Adult-onset hypophosphatemic osteomalacia as a cause of widespread musculoskeletal pain: A retrospective case series of single center experience. World J Clin Cases. 2023;11:7785. doi:10.12998/wjcc.v11.i32.7785
- Ko S, Kim HC, Kwon J. The effectiveness of vitamin D3 supplementation in improving functional outcome of non-surgically treated symptomatic lumbar spinal stenosis: Randomized controlled clinical trial - Pilot study. Medicine (Baltimore). 2023;102:e32672. doi:10.1097/MD.0000000000032672
- Evangelatos G, Kouna K, Iliopoulos A, Fragoulis GE. Musculoskeletal Complications of Celiac Disease: A Case-Based Review. Mediterr J Rheumatol. 2023;34:86. doi:10.31138/mjr.34.1.86
- Dechsupa S, Yingsakmongkol W, Limthongkul W, Singhatanadgige W, Jitjumnong M, et al. Vitamin D Inadequacy Affects Skeletal Muscle Index and Physical Performance in Lumbar Disc Degeneration. Int J Mol Sci. 2023;24. doi:10.3390/ijms24043152
- Scaturro D, Vitagliani F, Tomasello S, Sconza C, Respizzi S, et al. Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial. Medicina (Kaunas). 2023;59. doi:10.3390/medicina59122197
- Ko S, Kim HC, Kwon J. The effectiveness of vitamin D3 supplementation in improving functional outcome of non-surgically treated symptomatic lumbar spinal stenosis: Randomized controlled clinical trial - Pilot study. Medicine (Baltimore). 2023;102:e32672. doi:10.1097/MD.0000000000032672
- Zhang W, Li L, Zhou X, Li K, Liu C, et al. Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative Disorders. Spine (Phila Pa 1976). 2022;47:352. doi:10.1097/BRS.0000000000004309
- Ma Y, Wu X, Xiao X, Ma Y, Feng L, et al. Effects of teriparatide versus percutaneous vertebroplasty on pain relief, quality of life and cost-effectiveness in postmenopausal females with acute osteoporotic vertebral compression fracture: A prospective cohort study. Bone. 2020;131:115154. doi:10.1016/j.bone.2019.115154
- Pishgahi A, Dolatkhah N, Shakouri SK, Hashemian M, Amiri A, et al. Lower serum 25-hydroxyvitamin D3 concentration is associated with higher pain and disability in subjects with low back pain: a case-control study. BMC Res Notes. 2019;12:738. doi:10.1186/s13104-019-4768-0
- Krasowska K, Skrobot W, Liedtke E, Sawicki P, Flis DJ, et al. The Preoperative Supplementation With Vitamin D Attenuated Pain Intensity and Reduced the Level of Pro-inflammatory Markers in Patients After Posterior Lumbar Interbody Fusion. Front Pharmacol. 2019;10:527. doi:10.3389/fphar.2019.00527
- Moretti A, de Sire A, Curci C, Toro G, Gimigliano F, et al. Effectiveness of denosumab on back pain-related disability and quality-of-life in patients with vertebral fragility fractures. Curr Med Res Opin. 2019;35:151. doi:10.1080/03007995.2018.1545636
- Brady SRE, Naderpoor N, de Courten MPJ, Scragg R, Cicuttini F, et al. Vitamin D supplementation may improve back pain disability in vitamin D deficient and overweight or obese adults. J Steroid Biochem Mol Biol. 2019;185:212. doi:10.1016/j.jsbmb.2018.09.005
- Dzik K, Skrobot W, Flis DJ, Karnia M, Libionka W, et al. Vitamin D supplementation attenuates oxidative stress in paraspinal skeletal muscles in patients with low back pain. Eur J Appl Physiol. 2018;118:143. doi:10.1007/s00421-017-3755-1
- Englund M, Persson J, Bergström I. Lower pain and higher muscular strength in immigrant women with vitamin D deficiency following vitamin D treatment. Int J Circumpolar Health. 2017;76:1340547. doi:10.1080/22423982.2017.1340547
- Gaudio A, Fiore CE. Successful neridronate therapy in pregnancy-associated osteoporosis. Clin Cases Miner Bone Metab. 2016;13:241. doi:10.11138/ccmbm/2016.13.3.241
- Ghai B, Bansal D, Kanukula R, Gudala K, Sachdeva N, et al. Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial. Pain Physician. 2017;20:E99.
- Tanaka S, Yoshida A, Kono S, Oguma T, Hasegawa K, et al. Effectiveness of elcatonin for alleviating pain and inhibiting bone resorption in patients with osteoporotic vertebral fractures. J Bone Miner Metab. 2017;35:544. doi:10.1007/s00774-016-0791-6
- Polat SB, Evranos B, Aydin C, Cuhaci N, Ersoy R, et al. Effective treatment of severe pregnancy and lactation-related osteoporosis with teriparatide: case report and review of the literature. Gynecol Endocrinol. 2015;31:522. doi:10.3109/09513590.2015.1014787
- Gendelman O, Itzhaki D, Makarov S, Bennun M, Amital H. A randomized double-blind placebo-controlled study adding high dose vitamin D to analgesic regimens in patients with musculoskeletal pain. Lupus. 2015;24:483. doi:10.1177/0961203314558676
- Shin MY, Kang YE, Kong SE, Ju SH, Back MK, et al. A case of low bone mineral density with vitamin d deficiency due to prolonged lactation and severe malnutrition. J Bone Metab. 2015;22:39. doi:10.11005/jbm.2015.22.1.39
